IGF-1: Growth Hormones and Alzheimer’s

Insulin-like growth factor (IGF-1) is involved in both growth hormones and diabetes and is produced by the pituitary gland. Commonly in TBI we see damage to the pituitary/hypothalamic axis which results in lowered IGF-1/growth hormone levels. However, do not rely on IGF-1 testing alone after a TBI, the levels can be normal; do only a Glucagon tolerance test. IGF-1 is now thought to be involved in regulation of the human body’s “homeostasis” – or normal metabolic levels. Disruption can lead to Alzheimer’s and diabetes. IGF-1 itself shows promise as a possible therapy. (Zheng P. 2017).