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Latest Medical Research about Brain Injury

Updated: 1 June 2015


Another study, among many, showing observable objective changes in the brain after mild-TBI. Here brain volume in several parts of the brain, including the putamen, thalamus, amygdala and hippocampus seemed to be smaller than controls after the injury. They gradually resume most of their size after about a year, indicating recovery. (Zagorchev, L. et al. 2015).

Who is at Risk for Post Concussive Syndrome?

The study of those treated at an emergency room for mild TBI show the most commonly reported symptoms at first follow up where headache (27%), trouble falling asleep (18%), fatigue (17%), difficulty remembering (16%) and dizziness (16%). The following factors predict worse outcome:

  1. Consumption of alcohol prior to injury.
  2. The head injury resulted from a motor vehicle accident or fall.
  3. The presence of post injury headache.

Headache was more robustly associated with continued symptoms, more than loss of consciousness or alteration of consciousness or amnesia.


Methylene blue, an old well used drug, has proved to be neuroprotective to the brains of rats after a concussion. It was protective against the size of lesions and the length of functional cognitive deficits. Clinically trials are under way.


The prognostic value of DTI/MR was shown in 61 patients with mild TBI who were scanned early after trauma. The results of the abnormalities in white matter shown by DTI correlated with the patients lowered performance on neuropsychological testing and contrasted sharply with controls. DTI continues to prove itself as a biomarker for TBI in the human brain.


Microhemorrhages are one of the most common results of TBI, and with more powerful magnets and SWI/MR (Susceptibility Weighted Imaging), these micro hemorrhages can be identified. Taking it to another level, a program called SWIM (Susceptibility Weighted Imaging and Mapping) has been developed along with a Quantitative Susceptibility Mapping (QSM).

One of the problems with SWI is distinguishing between microhemorrhages and veins. These two programs substantially raise the accuracy of the identification of microhemorrhages. They can be done in a semi-automated manner with reasonable sensitivity and specificity. (Liu J. et al., 2015)


An article in the American Journal of Neuroradiology looked into the use of DTI/MR to study chronic TBI patients. It was assumed that the iron remnants of blood, which is what is seen by the SWI, would or could dissipate over years. However, they found that these microhemorrhage sites arising in the brain after a severe trauma are "time independent," meaning that they do not fade over time. Another question answered was whether or not these tiny "tissue tears" in the brain are hemorrhagic or non hemorrhagic. Studies had determined the answer both ways. The study determined that most but not all microhemorrhages involve a hemorrhagic (blood orientated) aspect.

They also establish that traumatic microbleeds are:

  1. Located mainly in the frontal lobe and temporal lobe.
  2. The white matter of the superior frontal gyrus was most often affected.
  3. That the traumatic microbleeds were situated mainly at the gray matter-white matter border. These were further located more often next to the crowns rather than the base of the gyral stalks. Most were bilateral.
  4. Periventricular hyperintensities, (like spots close to the hollow ventricles in the center of our brain), are reported to be present in 74% of young normal persons and 89% of elderly normal persons. Therefore it is very important for your doctor and lawyer to distinguish these rather common abnormalities from those caused by trauma, particularly by location.
Unfortunately, a comment is made "diffuse axonal injury is usually related to general poor clinical status." This statement is based on a 1991 paper written prior to even the discovery that DIA occurred in mild TBI. (Scheid R. et al. 2003)



Protein Molecule Protects and Repairs After TBI

The molecule PIF (Pre-Implantation Factor) which was discovered and isolated by Dr. E. Barnea in studies at Yale University, has shown to be neuro-protective for prenatal and traumatic brain injury. The molecule, which was discovered being secreted by all mammalian embryos to merge the immune system of mother and child, has been found to perform extraordinarily well as a anti-inflammatory and as a molecule that may control adult stem cells in human tissue repair. Human trials on PIF begin in September 2014 and should have application in all autoimmune diseases, inflammatory diseases and traumatic injuries - an extraordinarily wide ranging and paradigm breaking type of discovery.

Cannabis Helps PTSD

There has been so much self medication of sufferers from PTSD with marijuana that this discovery probably comes as no small surprise. The discovery of humans having an entire system within the human body called the endocannabinoid system, some ten years ago, has given rise to many discoveries and many more are going to be forthcoming. It is no surprise that, since the human body is wired and has a built system responding to THC and similar molecules, that marijuana has and will continue to show great promise in medicating human disease and symptoms.

Loss of Sleep = Smaller Brain

A recent study confirmed the general notion that the cognitive abilities of a human are diminished during periods involving lack of normal sleep. It has long been known that a person with diminished sleep will score more poorly on academic and cognitive testing. A more recent finding gives an explanation for the need for sleep - that during sleep the brain and its surrounding tissues and fluids are cleaned and washed. It is therefore no surprise that a recent study (Sexton CE et al. 2014) showed that in humans with reduced sleep, the volume of their brain was found to be diminished.

The value of sleep and lack of sleep has traditionally been talked about as a relatively unimportant phenomenon that has no lasting or systemic damage to our bodies, but this attitude must and will soon change as the biological and objective damages of disruptive sleep become more and more evident.

Injury to the Cerebellum Equals Autism

The cerebellum, located in the very back of the human brain, has long been thought to mostly be involved with coordination and smooth movement of the human body. More recently, some connections to memory were surprisingly found. Now, a recent study (Wang SSH, et al. 2014) has shown that early injury to the cerebellum in human infants can lead to autism. The breakdown in normal brain development occurs when injury to the cerebellum puts into motion an abnormal course of development of a child's brain. It was found that infants with cerebellum injury have a 36 times greater likelihood of developing autism than an uninjured child. This, of course, would include prenatal injuries as well.

Using Light in the Brain

Scientist at Massachusetts Institute for Technology, in a study published in Nature, have been able to alter or remove memories in a mouse's brain using light beams. Negative memories of a mild shock were removed completely by this method. They also found that neurons in the hippocampus area of the brain, involving memory, can be altered to make a bad memory less negative. These breakthroughs will promise in future research involving the origins and treatment of anxiety and depression.

Mild Traumatic Brain Injury and Long Term Consequences

A 2011 study (Komrad, C et al.) followed 33 individuals who had sustained a mild TBI for an average of six years versus 33 healthy controlled subjects. Comprehensive testing was done to assess cognitive and emotional functioning. The results showed that mild TBI victims had significant impairments in cognitive domains compared to the healthy controlled subjects, with the effect being described from medium to large. They noted "MTBI may lead to lasting disruption of neurofrontal circuits not detectable by standard structural MRI and needs to be taken seriously in clinical and forensic evaluation."

Worsening Symptoms after MTBI

The conventional medical wisdom is that symptoms of a mild traumatic brain injury are at their worse at the time of the trauma and thereafter always get better, not worse. However, studies have shown (Bleiberg, J et al. 1997) that this is not always the case, when they compared normal volunteers with persons suffering from MTBI. The injured group showed erratic and inconsistent performances on follow up testing, with some subjects showing worsening performance across days. This and other studies are showing that this intolerance to worsening symptoms over time has no medical basis.

Inaccuracy of Mild TBI Diagnoses at ER

Every year, thousands of victims of TBI are failed to be diagnosed with a mild brain injury because of emergency room failure to diagnose. In the study entitled "Accuracy of Mild Traumatic Brain Injury Diagnoses" (Powell JM, et al. 2008) medical documents were reviewed from emergency room examinations resulting in a finding that 56% of those actually suffering from a mild TBI did not have a documented and related diagnoses in the ER records. The greatest agreement between the persons studied and the ER physicians who gave a positive mild TBI diagnoses was for loss of consciousness, with the greatest discrepancy for the symptom of confusion.

This failure and confusion does great harm to those patients who developed enduring or permanent symptoms from MTBI and because of this failure of a baseline diagnosis, follow up medical providers and especially insurance companies, will tend to disregard a legitimate diagnoses of MTBI.

The Spinal Cord and Vertigo

You usually would not consider damage or problems in the cervical spine to have anything to do with the symptom of dizziness or vertigo. However, research entitled "The Implications of Cervical Spine Degeneration and Traumatic Diseases in the Pathogenesis of Cervical Vertigo and Hearing Loss" (Cobzeanu, MD et al. 2009) showed that there are receptors located in the spinal disc and cervical spine muscles which affect blood flow in the arteries. This causes a disruption in ear blood flow which can bring on hearing loss, vertigo and ringing in the ears (Tinnitus). This could help explain some of the strange and unexplainable symptoms often reported by persons who have suffered a severe whiplash. ENTs need to become aware of this research as soon as possible.

Stress and Brain Development

Stress causes problems in all kinds of human body systems. Stress hormones have been linked to a reduction in brain neurogenesis, or memory cell replacement in the human brain, located in the hippocampus. (Schoenfeld, TJ 2012). Chronic stress can rise after a TBI injury. Other research has shown that when animals are lowered in the pecking order of their society, that there is a great increase in stress hormones. TBI victims who lose cognitive ability, suffer personality changes, and financial devastation, are commonly and suddenly thrown into a lower societal level. Thus, this additional stress worsens the conditions already present in the injured TBI victim. Studies have shown that TBI victims with more supportive families, obviously, do much better. Perhaps this alleviates some of the stress hormones.

Gene Expression Following TBI

Epigenetics and gene expression are cutting edge concepts which are making their way into the realm of traumatic brain injury. A study (Staffa, K et al. 2012) looked at twelve cases of severe brain injury resulting in death and analyzed whether or not the brain tissue had gene expression different than controls without TBI. They found that several substances were expressed in the cerebellum indicating that the cerebellum is an important target to study further regarding gene expression after TBI. This means that adverse changes in a parent with TBI can be passed to children. (for more see blog)

Blast Wave Hurt Axon

Further expiration of the effects of a blast wave on the brain continue to shed light. Mice, after being exposed to a blast, showed cognitive and behavioral changes. It was noted that it was a shortening of the axon initial segment (AIS) in the cortex and hippocampus. This increases both the threshold and the ability of the firing neurons to perform normally and supports the conclusion that exposure to a single blast can lead to mild traumatic brain injury (mTBI) with accompanying cognitive impairment and subcellular changes in the molecular organization of neurons.

Barbiturate Coma After Severe TBI

The idea of putting patients into a barbiturate coma after serious TBI in order to reduce the intracranial pressure (ICP) has been around for years. It has been controversial, and a new study (Majdan, M et al. 2012 ) showed that in five European treatment centers, while high dose barbiturates decrease ICP in 69% of patients, it also caused longer periods of pressure instability, which is exceedingly dangerous. The analysis showed no significant effect on outcome at any stage after injury. Probably not worth doing.

Gender Effect on TBI Outcome?

A study utilizing the Chinese head trauma data bank (Gao, GY 2012) studied over 7000 patients to determine whether or not there was a statistical difference between males and females suffering from traumatic brain injury regarding outcome. There was not. Mortality rates and unfavorable outcomes, showed no gender difference.

Hope for Vision Loss after TBI

A recent study (Sabel BA, et al. 2010) has shown that retinal or cerebral visual injury, long considered irreversible, can be restored with vision rehabilitation techniques. They propose the name "residual vision activation theory" and suggest it can be started at all ages and in all types of visual field impairment after stroke or TBI.

Conflicting Data on Stromal Cell Implantation

In the Journal of Neurotrauma (Bonilla C, et al. 2010) a study tested the intravenous administration of bone marrow stromal cells after traumatic brain injury in rats. After two months of administration the rats were no better at functional abilities. A study of their brains in comparison with the normal group showed no changes in the brains of the mice who received the intravenous stromal cells. However, the same group of investigators in 2009 had implanted the stromal cells, rather than have them administered through IV and found that the rats showed progressive functional recovery and signs of increased brain volume and neurogenesis in the autopsy brains of the rats. This is consistent with earlier studies (Zurita M. 2004) in which the therapeutic effect of transplanted bone marrow stromal cells showed clear and progressive functional recovery of treated animals compared with controls. In that case, new spinal cord tissue was grown bridging the traumatic injury and restoring function.

Surgeons in India have had success with transplantation of stem cells into humans suffering from severe traumatic brain injury and coma. More than one patient in a coma has recovered consciousness and speech after the operation.

In addition, several new drugs and treatments are on the horizon which will give rise to increased neurogenesis or regrowth of brain cells after injury or trauma. Pre-implantation factor (PIF) has been shown to be neuro-regenerative in mice and further studies following a successful toxicity trial will be under way at several universities.

Current Status of Stem Cells for Spinal Cord Regeneration

Many attempts in the last fifteen years have been made to find a method for enhancing spinal cord regeneration after injury. These include use of embryonic or adult stem cells, Schwann cells, genetically modified fibroblast, bone stromal cells, and olfactory ensheathing cells. Out of all the types of cells, a recent study (Sobani ZA, et al. 2010) showed that olfactory ensheathing cells seem to be the most promising, followed by bone marrow stromal cells. However, in the United States direct transplantion of these cells for spinal cord regeneration is not yet out of the experimental stage.

A human trial carried out in Australia had cultured olfactory ensheathing cells transplanted into the spinal cords of six patients with paraplegia. No improvement was noted. However, a quadriplegia patient who was operated on 13 days after a quadriplegia break at C4-5 using cultured bone marrow stomal cells showed gradual improvement in six months following the surgery.

Nerve Repair with Fat Derived Stem Cells Successful

Peripheral nerves (those outside the brain or spinal cord) can often cause ongoing and devastating nerve pain in the extremities. Micro surgery often cannot address all of the cell death involved in some of these conditions. However, combining nerve repair with placement of fat derived stem cells in the dorsal root ganglia showed nerve regeneration and neuro-protection with significant reduction of symptoms. (Reid AJ, et al. 2001).

Important Finding on Coma Decisions

The horrible choices as to the true nature of injury and patients with vegetative or minimally conscious states is well known. Investigators using resting state EEG (Fingelkurts AA, et al. 2011) show that (1) the EEGs for non survivors were significantly lower than for survivors; (2) there was a higher probability of mostly delta and slow beta waves during first assessment for patients with bad outcome (i.e. those who died within the first six months); (3) patients with a good outcome had higher probability of mostly fast-beta and alpha oscillations. Therefore resting state EEGs may have a potentially prognostic value with regards to outcome from VS or MCS. This will also be potentially helpful in medical-legal end of life decision making.


A review of 25 years of treating survivors of brain injury in a university of Texas medical school study, shows that brain injury is a chronic ongoing process rather then a one time injury, as traditionally thought. The researchers hope to reclassify traumatic brain injury as a chronic disease, which will help researches with additional funding to investigate potential cures. They stress that neurological disorders can decrease life expectancy through sleep disorders, cardiac arrhythmia, or epilepsy. The disorders lead to gradual decline in cognitive functioning, a hosts of endocrine disorders, and psychiatric and psychological diseases.


A study of more than 900 homeless men and women in Toronto showed that an astonishing 58% of the homeless men and 42% of the homeless women have a history of traumatic brain injury. For many people, the first instance of brain injury occur at a young age, suggesting that it could have set off a chain of events leading to homelessness. The study again highlights the seriousness of brain injury to a life as a successful human being.


New research in the publication Neurology, showed that 13% of post traumatic epilepsy reported in head-wounded veterans did not show up until more than 14 years after the brain injury. A study found that the types of seizure changed over time, often becoming more severe.


A study (Ayalon, L 2007) showed that as many as 40% to 65% of people with mild traumatic brain injury suffer from insomnia.. The head injury patients underwent numerous sleep studies and found that 15 of 42 patients or 36% had circadian rhythm sleep disorder (CRSD) it was noted that these disorders can lead to psychological and cognitive problems and can interfere with rehabilitation.


Researchers at Emory University (Stien, D.G. 2009) found that progesterone can protect damaged cells in the central and peripheral nervous system following traumatic brain injury. They found it can reduce swelling and the restriction of blood supply after an injury. It also protects neurons from dying after trauma. Because of its known safety, low costs and ready availability, progesterone should be widely used very soon.


It is well known that a large percentage of those with mild or moderate brain injury can suffer from sleep apnea. I has also been observed that people with obstructive sleep apnea have a marked increase in the risk of severe motor crashes. A group of sleep apnea sufferers suffered 250 crashes over 3 years compared to 123 crashes in the group without sleep apnea.


Sleep disorders are common with TBI, but a recent study showed that after three months treatment with continuous positive air pressure (CPAP) reduced the severity of obstructive sleep apnea significantly. The participants suffering from TBI experienced no significant changes in the quality of life or cognitive performance after the treatment. Researchers believe that the other problems associated with traumatic brain injury may be continuing to effect the individuals even when they are largely eliminated. This is bad news for sufferers associated with TBI.


Scientist are using a new kind of scan called magnetoencephalopathy (MEG) in association with MRI to generate a detailed map that allows them to locate precise areas of the brain dysfunction and have them removed to stop epilepsy. Chronic epilepsy can be fatal and the ability of MEG to pinpoint the source of the seizure more accurately than the traditional method of EEG is a breakthrough that should help many patients with chronic epilepsy. The costs benefit analysis of doing brain surgery for epilepsy is now greater on the benefit side.


Seventy-four U.S. vets who were diagnosed with PTSD were scanned by a magnetoencephalopathy (MEG), a new non-evasive type of brain scan with more than 90% accuracy. Researchers were able to differentiate PTSD from health control. In addition, the MEG can show how badly the patients are impacted by the PTSD, possibly opening up the door to showing how badly patients are impacted by other brain disorders.


Using a non-evasive and relatively inexpensive EEG analysis and software, scientist have shown that an accurate diagnosis of early Alzheimer's can be made. A seven year NYU study revealed the program is 95% accurate in predicting cognitive decline. A brain wave called Theta was much more prominent in people likely to decline and was especially abnormal in the frontal regions of the brain. Especially the hippocampus.


Researchers at Clemson University in South Carolina have developed a gel, made partially of stem cells, that they are injecting into the brains of injured patients. People with combat wounds, car accident or gun shot wounds have been injected with the gel which has been shown to promote healing and limit the amount of secondary injury from the trauma. This is an exciting new method of reducing injury and improving outcome that has never been available before. The gel is expected to be ready for testing in humans in about three years.


A Swedish study (Horneman, G. 2009) followed 165 survivors of TBI and tested them 10 years after injury. The results showed poor performance in intellectual function, low results in verbal tests and tests of verbal learning and memory, visual ability and executive functioning. When compared to healthy controls, these deficits persisted. It again noted that it is difficult to predict the outcome in children and young adults until years after the injury.


Yet another biological marker for the presence of traumatic brain injury has been found. In a Chinese study (Huang, M. et al. 2009) the changes in plasma micro particle procoagulant activity in patients was correlated with brain injury and is thought to contribute to the inflammatory reaction after trauma. The higher presence of this product is associated with poorer clinical outcome.


For the past ten years the topic of whether or not lowering the body temperature of a recent victim of brain trauma, is or is not clinically helpful. This latest study (deDeyne, C.S. 2010) suggests that the clinical advantages of this procedure are not necessarily out weighted by the negative effects of cooling and re-warming a patient whose has been severely injured. The battle goes on and it is unclear where this one will end. Families of the patients who were offered this procedure need to make their own informed decision.


The Journal of Head Trauma Rehabilitation reported in 2010 (Larson, E.B.) that a negative effect on cognition was reported for TBI patients who were treated for insomnia with Benzodiazepins after injury. Furthermore, GABA antagonist agonists were found to possibly interfere with neuro-rehabilitation after injury. These types of medications should be avoided in the recovery phase of TBI. Pharmaceutical help in aiding sleep should be tailored to avoid these families of medications.


Although it is generally held that psychiatric conditions can be created or aggravated after TBI, there is a lot of research going on at the present time to quantify this. In the American Journal of Psychiatry, (Bryant R. A. et al. 2010) a study involving patients who had suffered mild traumatic brain injury (MmTBI) studied to see if new psychiatric disorders occurred after injury. Measurements three and twelve months post injury showed that 22% of the patients developed a psychiatric disorder they had not experience before injury, the most common being depression 9%, generalized anxiety disorder 9%, post traumatic stress disorder 6% and agoraphobia 6%. Other studies have shown higher rates.


It remains a mystery why certain individuals who suffer a mild or moderate TBI can have an excellent outcome, while others can suffer devastating effects. Comparing MRI or CT scans between the patients offers little to support the differences. Studies are now (Dardiotis, E. et al 2010) starting to accumulate evidence which implicates various genetic elements in the injury and recovery process of brain trauma. They note that "the extent of brain injury after TBI seems to be modulated to some degree by genetic variance." Further research on this important issue will be forthcoming. Patients should take comfort in these studies in cases where hope for recovery does not occur, as it is in some instances beyond the patients control.


The benefits of decompressive crainotomy (DC) in the treatment of traumatic brain injury patients with increased intracranial pressure (ICP) is controversial. A recent study Williams R. F. et al. 2009, showed that DC resulted in good functional outcome in over 50% of patients with severe TBI. The maximum benefit was observed in younger patients with demonstrable reduction in ICP after decompression. These are factors to consider when the choice of DC arises after injury.


Late onset seizures following moderate to severe brain injury are of great concern. They can emerge a year or two or more after the initial injury. A study (Englander, J. et al. 2003) showed that the highest probability for post traumatic seizures included biparietal contusions (66%), dural penetration with bone and metal fragments (62.5%), multiple intracranial operations (36%), multiple subcortical contusions (33%), subdural hematoma with evacuation (27%), midline shift greater than 5mm (25%). The initial Glasgow Coma Scale was associated with the following probabilities for developing late post traumatic seizures at 24-months: a score of 3 to 8, 17%, a score of 9 to 12, 24%, a score of 13 to 15, 8%.


Two new types of MRI of the brain - Diffusion Weighted Imaging (DWI) and Consequent Apparent Diffusion Coefficient (ADC) have been used as predictors of outcome in adults, and a recent study (Galloway, NR 2008), shows that these tools have excellent predictive capability in regards to children with traumatic brain injury. That found that ADC values in the peripheral white matter were significantly reduced in children with severe TBI with poor outcomes compared to those with severe TBI and good outcomes. They also found that the total brain ADC value alone had the greatest ability to predict outcome and correctly predicted outcome in 84% of cases. Thus, early identification of children in high risk for poor outcomes can be obtained using these tools and an assist in aggressive clinical management of these patients.


A review of the literature done in the journal Brain Injury (Radice-Meumann, D. et al 2007) shows that the TBI population often suffers from an impairment of their ability to determine the emotion of others from facial expressions. While this sounds odd, the results of this deficit result in poor interpersonal skills, which can affect social relationships, marriage, and rehabilitation. They suggest treatment approaches similar to those previously designed for autism to be considered with PT.


A large test of patients with mild traumatic brain injury and uninjured controls(Grebe, KW, 2009) showed that the widely used neuropsychological battery instrument tests, the "Wisconsin Card Sorting Test" failed to detect patients with a plan to perform below their ability or falsely on the tests. The scores were ineffective in discriminating malingering from non-malingering mild TBI patients.

Study in Norway (Siqurdardottir, S. 2009) studied post concussive symptoms from 3 to 12 months post injury in adults with TBI. Of the whole sample, 28% of cases developed those concussive syndromes at 3 months and 24% at 12 months post injury. The mild and moderate group showed a decline of symptoms over time in contrast to the severe TBI group. Greater levels of anxiety at 3 months, as well as shortness of post traumatic amnesia duration were found to be important predictors of the severity of these symptoms at 12 months. Interestingly, one year after injury, no differences were found between the TBI groups mild, moderate and severe on the presence of post concussive symdrome (PCS).

The second Norwegian study (Roe, C. et al. 2009) found that post concussive syndrome cognitive difficulties persisted for 12 months in a large percentage of the patients and that the cognitive symptoms persisted and were considered a ?considerable? problem even one-year after injury.


This is a well known phenomenon, a Chinese study from 2009 showed that moderate hypothermia (lowering the core temperature of the patient 10-degrees or so) showed improvements in intracranial temperature, intracranial pressure and other markers after severe brain injury. The temperature lowering was done for 72 hours after admission to the hospital and was considered safe in that clinical setting and successful.

Another study from 2009 shows that hypothermia when used with children suffering from brain injury reduces the damage caused to the brain post accident by "oxidative stress" which is a secondary form of injury that goes on in the brain following traumatic injury and which could have severe effects. The lowering of the temperature lowered the rate at which oxidated stress occurred and thus resulted in a better outcome for those treated with hypothermia.


The study following Iraq veterans suffering from TBI from blast injuries showed ongoing visual problems in a significant number (over 80%) following injury. The visual dysfunctions included problems with convergence, accommodative and ocular motor dysfunction, visual field defects and night vision. The study is important in that it validates, in a group in which no one can attack, the presence of these troubling visual problems often found in non-military brain injury settings. Insurance companies commonly scoff at these types of complaints, which are very real and objective.


A Turkish study from 2009 showed that the ingestion of alpha-lipoic acid (LA) produced inflamation and other symptoms after brain injury. It also reversed swelling due to increased water content. It is thought to exert its influence by helping preserve the brain blood barrier permeability and by its antioxidant properties.


A team at University of Pittsburgh has found that measuring the initial blood magnesium level of patients with brain injury indicted outcome from the injury. They found that patients who had a low magnesium level upon arrival at the hospital had significantly worse outcome than those with a normal magnesium level. It is hoped that more hospitals will begin to take this important measurement in the future.


It has been noted that resuscitation with a special hemoglobin oxygen-carrying solution may reduce the effects of secondary brain injury in patients who have had traumatic brain injury and bleeds. The solution called HBOC-201, is a salt solution that increases oxygen delivery to tissues. The studies are human should be taken soon.


A pallet study for the use of Quetiapine for treatment of aggression secondary to traumatic brain injury showed that it was effective in reducing irritability and aggression in such patients. Patients also reported an associated improvement in cognitive functioning.


The destructive cellular action known as Excitotoxicity occurs after TBI and results in brain cell death. A recent study in rats showed that older animals showed earlier onset of damage in wider areas then younger rats. This study shows, along with many others, that the effects of TBI on the elderly are often more significant than an equivalent injury in a middle aged person.


It was found that patients who developed mood disorder following traumatic brain injury has significantly lower hippocampal volume than patients without mood disturbance. Reduced hippocampus volumes were associated with poor vocational outcome in one year follow-up. The findings are consistent with the "double-hit" mechanism by which neural and glial elements affected by trauma are further damaged by the neuro-toxic effects of increased cortisol found in association with mood disorders. The need for volumetric studies of the hippocampus following moderate to severe brain injuries becoming more and more important.


Therapeutic hypothermia is a promising treatment for patients with severe TBI. Using a head cap and neck band filled with cooling material, patients who underwent such cooling after admission, had a far higher rate of good neurological outcome than those who did not. The non-evasive procedure is a safe method of improving the prognosis in severe TBI patients and hopefully this treatment will begin to be offered in the United States soon.


The presence of apoptotic cell death after mild traumatic brain injury in rats has been established. Selective neuronal cell loss was evident in several regions of the brain and the data suggest a biological basis for the permanent symptoms found in some mild TBI patients. (Raghupathi, R et al. 2002).


Following patients who reported mild TBI for an average of eight (8) years post injury, revealed that "MTBI can have adverse long term neuropsychological outcomes on subtle aspects of complex attention and working memory." (Danderploeg, RD 2005).


A European study from 2006 followed the progression of victims of MTBI and the results of follow-up neuropsychological testing showed "the idea that MTBI can have sustained consequences, and that the subjectively experienced symptoms and difficulties in every day situations are related to objectively measurable parameters in neuro-cognitive function." (Sterr A, et al. 2006).


A group of patients who had suffered mild traumatic brain injury were given a battery of test to determine the nature and rate of their recovery. The researchers noted "these findings indicate that the regions of the brain associated with orientating and executive components of visuospatial attention may be the most susceptible to neuro damage resulting from MTBI. Moreover, the lack of recovery in the executive component indicates that the degree and time course for recovery may be regionally specific." The findings show the deficits in executive functioning existed one month after trauma.


Researches tested mice following mild traumatic brain injury for up to 90 days post injury. There findings showed "these results demonstrate that persistent deficits in these tests of cognitive learning abilities and emergence of depression-like behavior in injured mice are similar to those reported in human post-concussion syndrome." (Milman A, et al. 2005).


The type of MRI now being utilized is know as Diffusion Tensor Imaging, promises to be more sensitive than normal MRI, especially in detection of white matter brain injury. It has the ability to see and is more sensitive to diffuse axonal injury and the effects of stretched neurons. Persons with ongoing TBI symptoms in the face of normal MRI should consider DTI to rule out more subtle damage. (Wilde EA et al. 2006).

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